The mechanism of the cord formation is not yet precisely understood.
2.
Moreover, there is delay in sex cord formation.
3.
If we additionally suppose that the tips try to keep some optimal absolute value ( cord formation, known in some fungal species.
4.
These initial Sertoli cells, in the center of the gonad, are hypothesized to be the starting point for a wave of FGF9 that spreads throughout the developing XY gonad, leading to further differentiation of Sertoli cells via the up-regulation of SOX9 . SOX9 and TDF are also believed to be responsible for many of the later processes of testis development ( such as Leydig cell differentiation, sex cord formation, and formation of testis-specific vasculature ), although exact mechanisms remain unclear.
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